黄赞

性    别

男

学历学位

生物学博士学位

职    称

副教授

导师类别

硕士生导师

专业领域

动物营养吸收和代谢

研究方向

脂肪发育与生理，肠道营养素感应

教育与工作经历

2003年-2007年，澳门新浦新京5197，国家生命科学技术与人才培养基地班，本科

2007年-2014年，南京大学，模式动物研究所，博士

2014年-至今，澳门新浦新京5197，副教授

2016年-2020年，美国明尼苏达大学，博士后

联系方式

huangzan@njau.edu.cn

奖励及荣誉

澳门新浦新京5197 钟山学术新秀

参加学术团体及任职情况

中国动物营养学会

美国糖尿病学会

承担科研项目

1、中央高校科研基本业务费 自主创新重点研究项目，主持，2015年

2、国家自然科学基金 青年项目，主持，2015年

3、江苏自然科学基金 青年项目，主持，2015年

4、国家重点研发计划，课题骨干，2017年

5、国家自然科学基金 面上项目，主持，2021年

论文论著：

1. Chen, Q., Shi, P., Wang, D., Liu, Q., Li, X., Wang, Y., Zou, D., Huang, Z., Gao, X., and Lin, Z. (2019a). Epidermis-Activated Gasdermin-A3 Enhances Thermogenesis of Brown Adipose Tissue through IL-6/Stat3 Signaling. The American journal of pathology 189, 1041-1052.

2. Chen, Q., Shi, P., Wang, Y., Zou, D., Wu, X., Wang, D., Hu, Q., Zou, Y., Huang, Z., and Ren, J. (2019b). GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity. Journal of molecular cell biology 11, 496-508.

3. Chen, W., Huang, Z., Jiang, X., Li, C., and Gao, X. (2015). Overexpression of myeloid differentiation protein 88 in mice induces mild cardiac dysfunction, but no deficit in heart morphology. Brazilian Journal of Medical and Biological Research 49. 共同第一作者

4. Chen, W., Wang, S., Xia, J., Huang, Z., Tu, X., and Shen, Z. (2016). Protein phosphatase 2A plays an important role in migration of bone marrow stroma cells. Molecular and cellular biochemistry 412, 173-180.

5. Gao, K., Pi, Y., Mu, C.L., Peng, Y., Huang, Z., and Zhu, W.Y. (2018). Antibiotics‐induced modulation of large intestinal microbiota altered aromatic amino acid profile and expression of neurotransmitters in the hypothalamus of piglets. Journal of neurochemistry 146, 219-234.

6. Huang, Z., Ruan, H.-B., Xian, L., Chen, W., Jiang, S., Song, A., Wang, Q., Shi, P., Gu, X., and Gao, X. (2014a). The stem cell factor/Kit signalling pathway regulates mitochondrial function and energy expenditure. Nature communications 5, 1-10. 共同第一作者

7. Huang, Z., Ruan, H.-B., Zhang, Z.-D., Chen, W., Lin, Z., Zeng, H., and Gao, X. (2014b). Mutation in the first Ig-like domain of Kit leads to JAK2 activation and myeloproliferation in mice. The American journal of pathology 184, 122-132. 共同第一作者

8. Huang Z, Zhang Z, Moazzami Z, Heck R, Hu P, Nanda H, Ren K, Sun Z, Bartolomucci A, Gao Y, Chung D, Zhu W, Shen S, Ruan HB. Brown adipose tissue involution associated with progressive restriction in progenitor competence. Cell Rep. 2022 Apr 12;39(2):110575.共同通讯作者

9. Jiang, S., Wang, Q., Huang, Z., Song, A., Peng, Y., Hou, S., Guo, S., Zhu, W., Yan, S., and Lin, Z. (2016). Gastric bypass surgery reverses diabetic phenotypes in Bdnf-deficient mice. The American journal of pathology 186, 2117-2128.

10. Lin, Z., Liu, F., Shi, P., Song, A., Huang, Z., Zou, D., Chen, Q., Li, J., and Gao, X. (2018). Fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase C. Stem cell research & therapy 9, 1-14.

11. Shen, J., Mu, C., Wang, H., Huang, Z., Yu, K., Zoetendal, E.G., and Zhu, W. (2020). Stimulation of Gastric Transit Function Driven by Hydrolyzed Casein Increases Small Intestinal Carbohydrate Availability and Its Microbial Metabolism. Molecular Nutrition & Food Research 64, 2000250.

12. Shi, P., Tang, A., Xian, L., Hou, S., Zou, D., Lv, Y., Huang, Z., Wang, Q., Song, A., and Lin, Z. (2015). Loss of conserved Gsdma3 self-regulation causes autophagy and cell death. Biochemical Journal 468, 325-336.

13. Tang, A., Shi, P., Song, A., Zou, D., Zhou, Y., Gu, P., Huang, Z., Wang, Q., Lin, Z., and Gao, X. (2016). PP2A regulates kinetochore-microtubule attachment during meiosis I in oocyte. Cell Cycle 15, 1450-1461.

14. Wang, Q., Tang, J., Jiang, S., Huang, Z., Song, A., Hou, S., Gao, X., and Ruan, H.-B. (2018). Inhibition of PPARγ, adipogenesis and insulin sensitivity by MAGED1. Journal of Endocrinology 239, 167-180.

15. Wang, Y., Shi, P., Chen, Q., Huang, Z., Zou, D., Zhang, J., Gao, X., and Lin, Z. (2019). Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation. Journal of molecular cell biology 11, 1069-1082.

16. Wu, J., Wang, J., Zeng, X., Chen, Y., Xia, J., Wang, S., Huang, Z., Chen, W., and Shen, Z. (2016). Protein phosphatase 2A regulatory subunit B56β modulates erythroid differentiation. Biochemical and biophysical research communications 478, 1179-1184. 共同通讯作者

17. Xian, L., Hou, S., Huang, Z., Tang, A., Shi, P., Wang, Q., Song, A., Jiang, S., Lin, Z., and Guo, S. (2015). Liver-specific deletion of Ppp2cα enhances glucose metabolism and insulin sensitivity. Aging (Albany NY) 7, 223.

18. Xiao, Y., Zhang, Y., Chen, Y., Li, J., Zhang, Z., Sun, Y., Shen, H., Zhao, Z., Huang, Z., and Zhang, W. (2019). Inhibition of microRNA-9-5p protects against cardiac remodeling following myocardial infarction in mice. Human gene therapy 30, 286-301.

19. Yu, M., Mu, C., Yang, Y., Zhang, C., Su, Y., Huang, Z., Yu, K., and Zhu, W. (2017). Increases in circulating amino acids with in-feed antibiotics correlated with gene expression of intestinal amino acid transporters in piglets. Amino Acids 49, 1587-1599.

20. Yu, Q., Zhang, Y., Zhang, Z., Zhu, W., and Huang, Z. (2019). Detection of Escherichia coli metabolites by luciferase reporter system to regulate secretion of cholecystokinin by STC-1 cells. Journal of Nanjing Agricultural University 42, 1133-1140.

21. Zhang, Z., Huang, Z., Ong, B., Sahu, C., Zeng, H., and Ruan, H.-B. (2019). Bone marrow adipose tissue-derived stem cell factor mediates metabolic regulation of hematopoiesis. Haematologica 104, 1731. 共同第一作者

22. Zhao, M., Ren, K., Xiong, X., Cheng, M., Zhang, Z., Huang, Z., Han, X., Yang, X., Alejandro, E.U., and Ruan, H.-B. (2020). Protein O-GlcNAc modification links dietary and gut microbial cues to the differentiation of enteroendocrine L cells. Cell reports 32, 108013.

23. Zhao, M., Xiong, X., Ren, K., Xu, B., Cheng, M., Sahu, C., Wu, K., Nie, Y., Huang, Z., and Blumberg, R.S. (2018). Deficiency in intestinal epithelial O‐GlcNAcylation predisposes to gut inflammation. EMBO molecular medicine 10, e8736.

24. Zou, J., Lai, B., Zheng, M., Chen, Q., Jiang, S., Song, A., Huang, Z., Shi, P., Tu, X., and Wang, D. (2018). CD4+ T cells memorize obesity and promote weight regain. Cellular & molecular immunology 15, 630-639.